2. Signaling Pathways
  3. GPCR/G Protein
  4. Neuromedin U Receptor (NMUR)

Neuromedin U Receptor (NMUR)

Neuromedin U Receptor

Neuromedin U Receptor belongs to the G protein-coupled receptors family and is classified as Class A. Neuromedin U Receptor can bind the neuropeptide hormones neuromedin U and neuromedin S. Neuromedin U Receptor includes NMUR1 and NMUR2. NMUR1 is mainly expressed in peripheral tissues such as the gastrointestinal tract, while NmU-R2 is mainly expressed in the central nervous system. Neuromedin U Receptor can mediate intracellular signal transduction such as Ca2+ and regulate the physiological functions of multiple systems such as the gastrointestinal tract, cardiovascular system, and neuroendocrine system, for example, affecting smooth muscle contraction, blood pressure, feeding, energy balance, and stress responses. Neuromedin U Receptor is closely related to the occurrence and development of diseases such as cancer, pain, metabolic diseases, and gastrointestinal diseases, and is a highly potential target for disease treatment[1].

Neuromedin U Receptor (NMUR) Isoform Specific Products:

Neuromedin U Receptor (NMUR) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-145086
    R-PSOP
    		Antagonist 99.90%
    R-PSOP is highly potent and selective nonpeptidic NMUR2 antagonist. R-PSOP binds to NMUR2 with the Kis of 52 and 32 nM for the human and rat NMUR2, respectively. R-PSOP shows moderate CNS penetration. R-PSOP can be used for the research of the eating disorders, obesity, pain, and stress-related disorders.
    R-PSOP
  • HY-P3030
    CPN-219
    		Agonist 98.13%
    CPN-219, a next-generation hexapeptidic NMUR2 agonist, achieves a dose-dependent and selective activation of NMUR2 with an EC50 value of 2.2 nM.
    CPN-219
  • HY-P5084
    Neuromedin S (human)
    		Modulator
    Neuromedin S (human) is a neuropeptide that contains 33 amino acids. Neuromedin S (human)has been identified in the brain as an endogenous ligand for the orphan G-protein coupled receptor (GPCR) FM-4/TGR-1 and acts on the neuromedin U (NMU) receptor 2 (NMUR2) in the regulation of body weight homeostasis.
    Neuromedin S (human)
  • HY-P10473
    CPN-351
    		Antagonist
    CPN-351 (compound 9a) is a selective antagonist of hNMUR1. CPN-351 can be used in the study of inflammation and cancer.
    CPN-351
  • HY-124681
    NY0116
    		Agonist
    NY0116 is a neuromedin U receptor 2 (NMUR2) agonist with EC50 values of 27.76 μM for hNMUR1 and 13.61 μM for hNMUR2. NY0116 decreases cAMP while stimulating calcium signaling in stably expressing NMUR2 HEK293 cells.
    NY0116
Neuromedin U Receptor (NMUR) Isoform Comparison

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